Yes and No.
Effective March 31st 2008 eBay has banned the sale of digital downloads using Auction and Fixed Price formats. The only listing type that is allowed for digital download goods is the "Classified Ads" format listing. Further information the eBay decision to limit digital download sales to classified ad style listings: New Policy - Digital Downloadable Goods in Classified Ads Format Only
To use DPD with eBay you simply need to create a product with the same price you intend to list on eBay and then copy and paste our buy button code into your classified ad listing body text area.
Viewers of your classified ad listing will be able to click on your DPD buy button, check out using PayPal or any other supported processor, and then receive an automatic secure delivery of their product after purchase.
There is nothing special you need to do in ebay or DPD for this to work- the eBay classified ad format is simply a static web page and DPD buy buttons will work without any further configuration.